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Table of Contents

Tuberculosis: Diagnostic and Therapeutic Considerations

Learning Objectives:

Tuberculosis: Diagnostic and Therapeutic Considerations

Tuberculosis: Historical trends

Tuberculosis Morbidity: 1993-1996

Causes for decline in Tuberculosis Cases

Failure to complete Tuberculosis therapy

Demographics of Tuberculosis: Age

Demographics of Tuberculosis: Race/Ethnicity

Demographics of Tuberculosis: Immigration

Demographics of Tuberculosis: Sex

Tuberculosis Case Definition

Diagnosis of tuberculosis: Tuberculin Skin test

Diagnosis of Tuberculosis

Diagnosis of Tuberculosis: Specimen Collection

Diagnosis of Tuberculosis: Specimen Collection

Diagnosis of Tuberculosis: Traditional Culture Methods

Diagnosis of tuberculosis: meaning of AFB Stain

Diagnosis of Tuberculosis: Molecular Technology

Principles of Treatment of Tuberculosis

Initial (bactericidal) Treatment of Tuberculosis

States with <4% isoniazid resistance

Rate of Initiation of Four Drug Initial Therapy

Maintenance (sterilizing) Treatment of Tuberculosis

Response to Therapy

Drug Resistant Tuberculosis

Second Line Drugs for Tuberculosis

Directly Observed Therapy

Other Issues

Take Home Messages: Diagnostic and Therapeutic Considerations for Tuberculosis

Internet Resources for Tuberculosis www.cdc.gov/nchstp/tb/dtbe.html www.med.upenn.edu/TBPA