Table of Contents
THERAPY OF TUBERCULOSIS
PPT Slide
Mycobacterium Tuberculosis
The disease
Medical treatments for tuberculosis in
the past
The Sanatorium Movement
PPT Slide
PPT Slide
First Effective antimicrobial chemotherapy
Lessons learned from early clinical trials
of TB drugs
New Medical Therapy of Tuberculosis
Reversal of a trend
Current status of tuberculosis control
Therapeutic agents for tuberculosis
The principles of therapy
Phases of TB Treatment
Activity of antituberculous drugs
Initial therapy: Four Drugs
PPT Slide
Need for 4 drug initial therapy
ISONIAZID
ISONIAZID RESISTANCE
RIFAMPIN
RIFAMPIN RESISTANCE
PYRAZINMIDE
ETHAMBUTOL
STREPTOMYCIN
STREPTOMYCIN RESISTANCE
Therapeutic Regimens
Completion of therapy
RISK FACTORS FOR RESISTANCE
Risk factors for resistance
Compliance with TB Therapy is Difficult:
Least Restrictive to Most Restrictive
Rate of Therapy Completion after Each
Legal Step
Directly observed therapy (DOT) vs Self
administered therapy (SAT)
Directly observed therapy (DOT) vs Self
administered therapy (SAT)
Completion of Therapy Rates
Completion Rates, DOT and SAT
Case Count: 1993-1997
Second line drugs
Characteristics of 2nd line therapy
Potential new agents
Rifapentine
Preventive therapy for tuberculous infection
Preventive therapy for tuberculous infection
New Short Course Preventive Therapy
Nontuberculous mycobacteria
Treatment of nontuberculous mycobacteria
Summary: Therapy of tuberculosis
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