Activity of antituberculous drugs

• Drug Activity pH Site*

• Isoniazid cidal neut-alk I/E

• Rifampin cidal/static neut-alk I/E

• Pyrazinamide cidal/sterilizing acid I/E

• Ethambutol cidal at 25mg/kg neut-alk I/E

  static at 15mg/kg
  

• Streptomycin cidal neut-alk E

  * = I = intracellular; E = extracellular
  

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