Phases of TB Treatment

• Bactericidal Phase:

• First two months

• Larger burden of TB

• More replication

• cidal drugs needed

• four drugs needed

• Key drugs: INH, PZA and Ethambutol

• Sterilizing Phase:

• Months 3-6

• Fewer organisms

• slower growth phase

• sterilizing drugs

• two drugs needed

• Key drug: Rifampin

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